What are the Most Addictive Prescription Pills?

prescription pills
Addictive Prescription Pills

What are the Most Addictive Prescription Pills? In the past, fueling an addiction often required driving to unsafe locations and dealing with less than wholesome people; now, it seems all that it takes to obtain an addictive medication is to visit a local pharmacy with a prescription in hand. Sadly, in the mind of most, pharmaceuticals aren’t associated with the negative stigma of being addictive. Because of this fatal misunderstanding, one may use much less caution when taking these medications, leading to physical and psychological dependence as well as problems in the future. Because of the devastating consequences of addiction to these pills, it’s necessary to know what the most addictive pharmaceuticals are.


Out of all prescription medications, opiates are easily one of the most addictive. All opiates and opioid receptor agonists can cause dependence, especially if taken for a sustained period of time. Additionally, opiates are rated one of the most euphoric drugs available, prescription or not, making them prime candidates for the most addictive drugs.


While Percocet is a combination of oxycodone and acetaminophen, it is one of the most highly abused opiate pain medications available. Because Percocet contains acetaminophen, it is much harder to abuse than various other opiates without sustaining liver damage. Sadly, the threat of liver damage does not deter many with a serious addiction. Even at relatively low doses, the oxycodone in this pill can cause dependence and addiction.

Roxycontin & Oxycontin

Roxycontin is an instant release form of oxycodone, which is available in 15 milligram and 30 milligram doses. These small pills are popularly abused because they have no abuse prevention mechanisms. Because this pill is instant release oxycodone, and standard fillers and binders, they are commonly insufflated intranasally; many even extract the oxycodone into water or another solution and inject them intravenously.

Oxycontin, on the other hand, is an extended-release oxycodone pill. Since the creation of Oxycontin, Purdue Pharma has added a variety of abuse deterrents, making them much more difficult to abuse. For those struggling with addiction to Roxycontin or Oxycontin pills, inpatient rehabilitation can help remove one from the environment that makes it easy to abuse this medication, as well as help assist one medically while getting out of physical opiate dependence.


Opana is on the rise and may become the most commonly abused opiate medication. This medication contains the most powerful opiate derivative, which is stronger than heroin per milligram. While Opana does have abuse deterrents, they are still easily abusable intranasally without getting more than a congested nose. Additionally, their nasal bio availability is 3-5 times higher than orally, making them extremely powerful when taken in this dangerous fashion.


Stimulants are also very commonly abused, as they can drastically increase brain-concentrations of dopamine, which can cause heavy feelings of euphoria. There are two primary types of addictive stimulants, amphetamines and dopamine reuptake inhibitors.


Because Adderall is very commonly prescribed for ADD and ADHD, they are often easy for many to acquire. Adderall is a mix of different amphetamine salts, amphetamine, and dextroamphetamine. This medication is available in both instant release and time release versions without any effective abuse deterrents.

Ritalin & Concerta

Both Ritalin and Concerta are pharmaceutical pills that contain methylphenidate, a powerful dopamine reuptake inhibitor. These medications, while not as potent as their amphetamine counterparts, are still very commonly abused despite deterrents in the time release versions.


Some of the most commonly abused medications are benzodiazepines, anti-anxiety pills that affect gaba receptors, resulting in a feeling of calm. Because withdrawal from benzodiazepines can cause seizures and even death, it is essential to seek inpatient rehabilitation if addicted.


One of the most commonly recognized, and abused, benzodiazepines is Xanax, which contains the fast-acting chemical alprazolam. The reason these are so commonly abused is because of their quick onset, which can create feelings of euphoria in many.


Another commonly abused benzodiazepine is Klonopin, which contains clonazepam. Unlike Xanax, Klonopin is a very long-lasting drug; because of Klonopin’s long half-life, it is much easier to accidentally increase one’s dose, believing that the drug has worn off. These constant gaba receptor agonist effects can lead to a strong dependency and a severe withdrawal in a fairly short period of time, especially at high doses.


Very similar to clonazepam, diazepam has a long half-life and duration of effects. While not rated as addictive as Xanax, physical addiction can quickly occur if not careful with dose.

While new addictive prescription pills come out regularly, the three primary categories of addictive pills to watch out for are painkillers, benzodiazepines, and stimulants. While barbiturates and sleeping medications can also be addictive, they are less euphoric and less prescribed than their counterparts. For those who are battling an addiction to any of these pills, especially benzodiazepines, inpatient rehabilitation may be necessary in order to keep oneself clean and create a healthy lifestyle long-term.

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